鏂?| 闄?涓?鍗?/span>

瀹?鏍?| 寮?灏?绾?/span>

鍖?浜?澶?瀛?棣?閽?鍖?闄?/span>

鍥?鐗?| 婧?鑷?缃?缁?/span>

鏈€杩戯紝鎴戞帴鍒板ソ鍑犱綅鏈嬪弸鐨勫挩璇㈤棶棰橀兘鏄拰鎬€瀛曞拰琛ュ厖鍙堕吀鏈夊叧锛屾瘮濡傦細鈥滄垜鍑嗗鎬€瀛曪紝鏈夋病鏈夋帹鑽愮殑鍙堕吀锛熲€濓紝鈥滄€€瀛曠殑鏃跺€欏悆鍙堕吀锛屽埌搴曟槸鍚冩櫘閫氬彾閰稿ソ锛岃繕鏄悆澶嶅悎缁寸敓绱犲ソ锛熲€濓紝鈥滄垜鎬€瀛曚箣鍓嶆煡杩囧彾閰革紝鍖荤敓璇村彾閰告按骞充綆锛岀幇鍦ㄦ€€瀛曚箣鍚庯紝瑕佷笉瑕佸鍚冪偣鍙堕吀锛熲€濓紝鈥滄垜濮愬鐢熻繃鍏堝ぉ鎬ц剳绉按鐨勫瀛愶紝鍖荤敓璇村鏋滃啀鎬€瀛曡鍚冨ぇ鍓傞噺鍙堕吀锛屾垜鍑嗗鎬€瀛曪紝鏈変粈涔堟敞鎰忎簨椤瑰悧锛熲€濃€︹€?/span>

涓嬮潰锛屽挶浠氨鏃╁瓡鏈熼棿琛ュ厖鍙堕吀鐨勯棶棰樿亰涓€鑱娿€?/p>

鍏堜粠鍙堕吀璇磋捣

鍙堕吀鍙備笌姘ㄥ熀閰稿拰鏍搁吀鐨勪唬璋紝瀵圭粏鑳炲娈栥€佺粍缁囧垎鍖栧拰鏈轰綋鐢熼暱鍙戣偛鍧囧叿鏈夐噸瑕佷綔鐢ㄣ€傚彾閰稿湪浜轰綋鍐呬笉鑳藉悎鎴愶紝浠呰兘浠庨鐗╀腑鎽勫彇锛屽瓡鏈熸瘝浣撶敓鐞嗘€у彉鍖栧拰鑳庡効鐢熼暱鍙戣偛绛夊鑷村鍙堕吀鐨勯渶瑕侀噺澧炲姞銆?span style=”color: #D92142; –tt-darkmode-color: #D92142;”>缁垮彾钄彍銆佽眴鍒跺搧銆佸姩鐗╄倽鑴忋€佺槮鑲夈€佽泲绫荤瓑鏄彾閰哥殑鑹ソ椋熺墿鏉ユ簮銆傚瘜鍚彾閰哥殑椋熺墿鍖呮嫭钘滈害銆佸共澶ц眴鎴栨潅璞嗐€佽厫绔广€佽彔鑿溿€佽尨棣欍€佽媼鑿溿€佸姩鐗╄倽鑴忋€佺槮鑲夈€侀腑铔?/span>绛夈€?/span>

铏界劧澶╃劧椋熺墿涓殑鍙堕吀鐩稿瀹夊叏锛屼絾鐢变簬鍏剁粨鏋勪笉绋冲畾锛堥鐗╁姞宸ヨ繃绋嬩腑瀹规槗琚牬鍧忥級銆佺敓鐗╁埄鐢ㄧ巼杈冧綆锛屼笖鍏跺湪浣撳唴鐨勫惛鏀跺埄鐢ㄥ彈鑽墿銆侀厭绮俱€佸叾浠栬惀鍏荤礌缂轰箯绛夎澶氬洜绱犲奖鍝嶏紝鍗充娇瀵逛簬涓€鑸汉缇わ紝鍙堕吀鎽勫叆閲忎篃杈冮毦婊¤冻鎺ㄨ崘鎽勫叆閲忥紱灏ゅ叾瀵逛簬鍙堕吀缂轰箯楂樺嵄浜虹兢锛屾瘮濡備腑鍥藉寳鏂瑰湴鍖恒€佽传鍥板啘鏉戙€佸啲/鏄ュ銆佸瓡濡?涔虫瘝銆侀暱鏈熸湇鐢ㄦ嫯鎶楀彾閰镐唬璋㈣嵂鐗┿€佸ぇ閲忛ギ閰掋€佹煇浜涚柧鐥呫€佸彾閰镐唬璋㈠熀鍥犲彉寮傜瓑鐗瑰緛浜虹兢锛屽簲杩涗竴姝ラ噰鐢ㄥ彾閰歌ˉ鍏呮垨寮哄寲椋熺墿绛夋帾鏂?/span>锛屼互鏀瑰杽鍙堕吀缂轰箯/涓嶈冻鐘跺喌銆?/span>

涓€鑸汉缇ゅ彾閰歌ˉ鍏呯殑鏈夋晥涓斿畨鍏ㄥ墏閲忎负0.4~1.0mg/d锛岄渶娉ㄦ剰鐨勬槸锛岄暱鏈熷ぇ鍓傞噺锛?gt;1mg/d锛夎ˉ鍏呭彾閰革紙鍖呮嫭鍙堕吀寮哄寲椋熺墿锛夋湁鍙兘浜х敓鍋ュ悍椋庨櫓锛屽澧炲姞鏌愪簺鐧岀棁锛堝缁撶洿鑲犵檶銆佸墠鍒楄吅鐧岋級椋庨櫓銆佹帺鐩栫淮鐢熺礌B12缂轰箯鐨勬棭鏈熻〃鐜般€佸姞閲嶇缁忕郴缁熼€€琛屾€х梾鍙樸€佷笌鍏朵粬鑽墿鐩镐簰骞叉壈銆佸奖鍝嶉攲鍚告敹銆侀檷浣庡彾閰稿惛鏀剁巼銆侀檷浣庡厤鐤姏绛夈€?/span>

鎵€浠ワ紝骞宠　鑶抽銆佸悎鐞嗕娇鐢ㄥ彾閰歌ˉ鍏呭墏鍜屽己鍖栭鐗?/span>鏄敼鍠勫彾閰歌惀鍏荤姸鍐电殑鏈夋晥鎺柦锛屽嵆浣块€夋嫨鍙堕吀琛ュ厖鍓傛垨寮哄寲椋熺墿锛屼篃搴斿缓绔嬪湪骞宠　鑶抽鐨勫熀纭€涓娿€傚彾閰稿湪浣撳唴鐨勪唬璋㈠彈澶氬洜绱犲奖鍝嶏紝鍦ㄥ埗璁㈠彾閰歌ˉ鍏呮柟妗堟椂闇€鑰冭檻閬椾紶銆佺敓鐞嗙姸鎬併€佺柧鐥呫€佺敤鑽€佺敓娲绘柟寮忋€佸叾浠栫浉鍏宠惀鍏荤礌鐘跺喌绛夛紝鍋氬埌涓€у寲琛ュ厖锛屽苟閬垮厤杩囬噺琛ュ厖甯︽潵鐨勫仴搴烽闄┿€?/span>

澶囧瓡銆佸瓡鏃╂湡濡囧コ濡備綍瀹夊叏鍚堢悊琛ュ厖鍙堕吀锛?/span>

瀵逛簬涓€鑸汉缇わ紝涓撳浠帹鑽愶細

锛?锛夋棤楂樺嵄鍥犵礌鐨勫濂筹紝寤鸿浠庡彲鑳藉濞犳垨瀛曞墠鑷冲皯3涓湀寮€濮嬶紝澧炶ˉ鍙堕吀0.4 mg/d鎴?.8 mg/d锛岀洿鑷冲濞犳弧3涓湀銆?/span>

锛?锛変釜鎬у寲澧炶ˉ锛氬瓨鍦ㄤ互涓嬫儏鍐电殑濡囧コ锛屽彲閰屾儏澧炲姞琛ュ厖鍓傞噺鎴栧欢闀垮瓡鍓嶅琛ユ椂闂达細鈶犲眳浣忓湪鍖楁柟鍦板尯锛屽挨鍏跺寳鏂瑰啘鏉戝湴鍖猴紱鈶℃柊椴滆敩鑿滃拰姘存灉椋熺敤閲忓皬锛涒憿琛€娑插彾閰告按骞充綆锛涒懀澶囧瓡鏃堕棿鐭€?/span>

锛?锛夊缓璁瀛曞拰瀛曟棭鏈熷濂冲椋熺敤瀵屽惈鍙堕吀鐨勯鐗╁缁垮彾钄彍鍜屾柊椴滄按鏋滐紝鍏绘垚鍋ュ悍鐨勭敓娲绘柟寮忥紝淇濇寔鍚堢悊浣撻噸锛屼粠鑰岄檷浣庤儙鍎縉TDs锛?/span>绁炵粡绠＄己闄凤級鐨勫彂鐢熼闄┿€?/span>

鍥村彈瀛曟湡鍙堕吀缂轰箯鏄捐憲澧炲姞NTDs鍙戠敓椋庨櫓

NTDs鏄寚鑳氳儙鍙戣偛杩囩▼涓洜绁炵粡绠￠棴鍚堝け璐ヨ€屽鑷寸殑涓灑绁炵粡绯荤粺鍑虹敓缂洪櫡锛岃儙鍎垮彂鐥呯巼涓?鈥皛1%锛屽叾褰㈡垚鏈哄埗闈炲父澶嶆潅锛屾槸閬椾紶鍥犵礌鍜岀幆澧冨洜绱犲叡鍚屼綔鐢ㄧ殑缁撴灉銆?/span>

姣嶄綋鍙堕吀姘村钩涓嶈冻鍙兘寮曡捣鑳庡効绁炵粡绠￠棴鍚堥殰纰嶏紝瀵艰嚧NTDs銆傚瓡鍓嶅拰瀛曟湡琛ュ厖鍙堕吀鍙樉钁楅檷浣嶯TDs鍙戠敓椋庨櫓銆備竴椤瑰湪寰峰浗鑲查緞濂虫€т腑寮€灞曠殑闅忔満瀵圭収璇曢獙鍙戠幇锛屾瘡鏃ユ湇鐢ㄥ彾閰?.8mg锛屽湪4~8鍛ㄥ唴鍙揪鍒伴闃睳TDs姘村钩锛岃€屾瘡鏃ユ湇鐢?.4mg鍒欐棤娉曞湪鍚屾牱鏃堕棿鍐呰揪鍒拌姘村钩銆?/span>

鎴戝浗鍖楁柟鍐滄潙鍦板尯濡囧コ琛€娑插彾閰告按骞宠緝浣庯紝涓€椤归殢鏈哄鐓ц瘯楠岀粨鏋滄樉绀猴紝鎴戝浗鍖楁柟鍐滄潙鍦板尯鑲查緞濡囧コ鏈嶇敤鍙堕吀0.4mg/d锛岃嚦灏戦渶瑕?涓湀锛岀孩缁嗚優鍙堕吀姘村钩鎵嶈兘杈惧埌棰勯槻NTDs鐨勬按骞炽€傛澶栵紝鎻愰珮鑶抽鍙堕吀鎽勫叆閲忥紝涔熷彲浣胯儙鍎縉TDs鍙戠敓椋庨櫓闄嶄綆30%~60%銆?/span>

瀛曟湡鍙堕吀缂轰箯杩樺鍔犳祦浜с€佹棭浜с€佹鑳庛€佸法骞肩粏鑳炶传琛€銆佸瓙鐥墠鏈熺瓑鐤剧梾鍙戠敓椋庨櫓锛岃€岃ˉ鍏呭彾閰稿彲闄嶄綆娴佷骇绛夐闄┿€傚彟涓€鏂归潰锛屽彾閰镐娇鐢ㄨ繃閲忓瓨鍦ㄥ鍔犲濞犳湡楂樿鍘嬬殑娼滃湪椋庨櫓銆傚瓡鏃╂湡鑷冲瓡涓湡澶у墏閲忥紙鈮?.8mg/d锛夎ˉ鍏呭彾閰镐細澧炲姞缃规偅濡婂鏈熼珮琛€鍘嬪拰濡婂鏈熺硸灏跨梾鐨勯闄┿€傛瘝浣撳彾閰告按骞宠繕鍙兘涓庡瓙浠ｅ鐙棁璋辩郴闅滅锛坅utism spectrum disorder,ASD锛夌殑鍙戠敓椋庨櫓鐩稿叧銆傛瘝浣撳彾閰告按骞充笌浜у悗鎶戦儊鐩稿叧锛屼絾鐩墠缁撹骞朵笉涓€鑷淬€傛墍浠ワ紝澶囧瓡鍜屽瓡鏃╂湡鍙堕吀钀ュ吇鐘跺喌瀵规瘝鍎垮仴搴风粨灞€鑷冲叧閲嶈銆?/span>

瀵逛簬鐗规畩浜虹兢锛屼笓瀹朵滑鎺ㄨ崘鏂规锛?/span>

锛?锛塏TDs鐢熻偛鍙插濂冲缓璁粠鍙兘濡婂鎴栧瓡鍓嶈嚦灏?涓湀寮€濮嬶紝澧炶ˉ鍙堕吀4mg/d锛岀洿鑷冲濞犳弧3涓湀锛涘洜鍥藉唴鍓傚瀷鍘熷洜锛屽彲澧炶ˉ鍙堕吀5mg/d銆?/span>

锛?锛夊か濡讳竴鏂规偅NTDs锛屾垨鐢锋柟鏃㈠線鏈塏TDs鐢熻偛鍙诧紝寤鸿澶囧瓡濡囧コ浠庡彲鑳藉濞犳垨瀛曞墠鑷冲皯1涓湀寮€濮嬶紝澧炶ˉ鍙堕吀4mg/d锛岀洿鑷冲濞犳弧3涓湀锛涘洜鍥藉唴鍓傚瀷鍘熷洜锛屽彲澧炶ˉ鍙堕吀5mg/d銆?/span>

锛?锛夋偅鍏堝ぉ鎬ц剳绉按銆佸厛澶╂€у績鑴忕梾銆佸攪鑵銆佽偄浣撶己闄枫€佹硨灏跨郴缁熺己闄凤紝鎴栨湁涓婅堪缂洪櫡瀹舵棌鍙诧紝鎴栦竴銆佷簩绾х洿绯讳翰灞炰腑鏈塏TDs鐢熻偛鍙茬殑濡囧コ锛屽缓璁粠鍙兘濡婂鎴栧瓡鍓嶈嚦灏戯紦涓湀寮€濮嬶紝澧炶ˉ鍙堕吀0.8~1.0 mg/d锛岀洿鑷冲濞犳弧3涓湀銆?/span>

锛?锛夋偅绯栧翱鐥呫€佽偉鑳栥€佺櫕鐥€佽儍鑲犻亾鍚告敹涓嶈壇鎬х柧鐥咃紝鎴栨鍦ㄦ湇鐢ㄥ鍔犺儙鍎縉TDs鍙戠敓椋庨櫓鑽墿鐨勫濂筹紝濡傚崱椹タ骞炽€佷笝鎴婇吀銆佽嫰濡ヨ嫳閽犮€佽嫰宸存瘮濡ャ€佷簩鐢插弻鑳嶃€佺敳姘ㄨ澏鍛ゃ€佹煶姘：鍚″暥銆佺敳姘ц媱鍟躲€佹皑鑻澏鍟躲€佽€冩潵鐑兒绛夛紝寤鸿浠庡彲鑳藉濞犳垨瀛曞墠鑷冲皯3涓湀寮€濮嬶紝澧炶ˉ鍙堕吀0.8~1.0mg/d锛岀洿鑷冲濞犳弧3涓湀銆?/span>

锛?锛夐珮Hcy琛€鐥囧濂筹紝寤鸿澧炶ˉ鍙堕吀鑷冲皯5mg/d锛屼笖鍦ㄨ娓匟cy姘村钩闄嶈嚦姝ｅ父鍚庡啀鍙楀瓡锛屽苟鎸佺画澧炶ˉ鍙堕吀5mg/d锛岀洿鑷冲濞犳弧3涓湀銆?/span>

锛?锛塎THFR 677浣嶇偣TT鍩哄洜鍨嬪濂筹紝鍙牴鎹釜浣撴儏鍐甸厡鎯呭鍔犺ˉ鍏呭墏閲忔垨寤堕暱瀛曞墠澧炶ˉ鏃堕棿銆?/span>

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鐧棲濡囧コ瀛曞墠琛ュ厖鍙堕吀鍙檷浣庡叾鍚庝唬鍙戠敓瀛ょ嫭鐥囩殑椋庨櫓锛屽瓡鍓嶈偉鑳栧拰瀛曞墠绯栧翱鐥呭琛ュ彾 閰?鍙?闄?浣?鑳?鍎?NTDs 鐨?鍙?鐢熼闄╋紝瀛曞墠鍜屽瓡鏈熺殑鑽墿鍜屾瘨鐗╂毚闇蹭篃澧炲姞瀛愪唬缃规偅ASD鐨勯闄╋紝鑰岃ˉ鍏呭彾閰稿彲闄嶄綆鐩稿叧椋庨櫓銆?/span>

瀛曟湡姣忔棩鎽勫叆0.8mg鍙堕吀涓斿悓鏃舵湁瀹ゅ唴鍐滆嵂鏆撮湶鍙茬殑瀛曞锛屽叾瀛愪唬鍑虹敓鍚庢偅ASD鐨勯闄╂槸鏃犲啘鑽毚闇插彶瀛曞鐨?.7鍊嶏紝鑰屽彾閰告憚鍏ラ噺涓嶈冻0.8mg/d鐨勫瓡濡囷紝鍏跺瓙浠ｆ偅ASD鐨勯闄╁鍔犱簡2.5鍊嶃€傛墍浠ワ紝鐗规畩浜虹兢鐨勫瀛曞拰瀛曟棭鏈熼渶鏍规嵁鍏蜂綋鎯呭喌杩涜涓€у寲鍙堕吀琛ュ厖銆?/span>

鍦ㄨ繖閲岃浜嗚繖涔堝锛屼笉鐭ラ亾澶у娓呮浜嗘病鏈夛紝濡傛湁涓嶆槑鐧斤紝娆㈣繋鏉ラ棬璇婂挩璇€?/span>

鍏充簬鏃╁瓡鏈熼棿琛ュ厖鍙堕吀鐨勫嚑涓皬闂,瀛曟棭鏈熶竴瀹氳琛ュ厖鍙堕吀鍚?/strong>